Studies on chiral organo-sulfur compounds. I. Asymmetric synthesis of sulfoxides with optically active o-aminoalkylphenol derivatives.
نویسندگان
چکیده
منابع مشابه
Application of chiral sulfoxides in asymmetric synthesis
Over the last three decades, the sulfinyl group has received considerable attention in asymmetric synthesis1‒5 as a chiral tool. The sulfinyl group is widely used as to bring about numerous asymmetric transformations. The effectiveness of the sulfoxide in diastereoselective auxiliary-induced reactions is mainly due to the steric and stereo electronic differences existing between the substituent...
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Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding alpha-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imid...
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This account outlines the results obtained in the author’s laboratory on the asymmetric cyclopropanation of enantiopure 1-phosphorylvinyl p-tolyl sulfoxides with sulfur ylides and diazoalkanes. Based on experimental results and theoretical calculations, the transition-state model for asymmetric cyclopropanation is proposed. A great synthetic value of the reaction investigated is exemplified by ...
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60%; [a]25D -13.4O (c 0.7, MeOH);24 'H NMR (CDCld 8 0.95 (3 H, d, J = 6.0 Hz), 1.40-2.00 (3 H, m), 2.15 (2 H, br s), 3.30-3.90 (4 H, m). Synthesis of 10. This compound was synthesized by starting from cis-3Dc as reported above for cis-3Ac. The diastereomeric ratio has been obtained by capillary GC analysis (150 OC 0 min/4 OC/min/250 OC 5 min, tR = 13.72 (major), 14.10 (minor)). The yield is rep...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1983
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.31.3471